ELIGARD (leuprolide acetate) is indicated for the palliative due to incorrect reconstitution or administration of the product (see Monitoring and Laboratory .. Gently insert the long, white replacement plunger rod into the gray. PACKAGE LEAFLET: INFORMATION FOR THE USER. ELIGARD 45 mg powder and solvent for solution for injection. Leuprorelin acetate. Read all of this leaflet. Eligard® is a sterile polymeric matrix formulation of leuprorelin acetate for subcutaneous package insert for constitution and administration procedures.
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Monitor hormonal and clinical parameters at month 1 to 2, with dose changes, and further as appropriate to ensure adequate suppression.
Eligard (leuprolide acetate) dose, indications, adverse effects, interactions from
An interruption or discontinuation of sorafenib therapy may be necessary if QT prolongation occurs. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include droperidol. For the preoperative treatment of anemia due to uterine leiomyomata fibroids in combination with iron supplementation when iron therapy alone fails to correct the anemia.
In clinical trials, patients receiving the In another case report, a year old male with idiopathic recurrent priapism received 7. Because of the potential for TdP, use of cisapride with leuprolide is contraindicated. Insert the needle at a 90 degree angle into the gluteal area, anterior thigh, or shoulder. Because of the potential for TdP, use of dofetilide with leuprolide is contraindicated.
In clinical trials, patients receiving the 7. The recommended dose is Moderate Lithium should be used cautiously with leuprolide.
If these drugs are used together, consider electrocardiogram monitoring. Synthetic analog of gonadotropin-releasing hormone GnRH ; substitution of two amino acids normally found in GnRH leads to sustained activity Approved uses include endometriosis, precocious puberty, prostate cancer, and uterine leiomyomata; off-label uses include benign prostatic hyperplasia BPHbreast cancer, infertility, premenstrual syndrome PMSand stuttering priapism Pregnancy category X.
Antipsychotic-induced hyperprolactinemia results in down-regulatation of the number of pituitary GnRH receptors and may interfere with the response to any of the gonadotropin-releasing hormone GnRH analogs e.
If concurrent therapy is considered essential, ECG monitoring is recommended.
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. HCG is then administered to induce final follicular maturation for oocyte retrieval. Minor Androgen deprivation therapy e. Severe Androgen deprivation therapy e. According to the manufacturer, bepridil is contraindicated for use with drugs that prolong the QT interval due to the risk of TdP.
An exploratory survival analysis favored leuprolide at 5 years HR 1. The product must be mixed as described; shaking the product will not provide adequate mixing of the product. Several dosage regimens are possible, depending on the depot dosage used. Be sure to rotate injection sites when dose is next due. Because of the potential for TdP, dofetilide is contraindicated with inesrt drugs associated with QT prolongation.
Once every 3 months regimen.
Major Avoid coadministration of glasdegib with leuprolide due to the potential for additive QT prolongation. Children 2 to 11 years. The authors pzckage that LHRH-agonist therapy cannot be routinely recommended to augment height in short adolescents with normally timed puberty; for most adolescents the potential benefit of treatment would not outweigh the risks.
Major Citalopram causes dose-dependent QT interval prolongation.
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Use leuprolide with caution in patients with depression and emotional instability; monitor patients for worsening of psychiatric symptoms during treatment with leuprolide. Drugs with a possible risk for QT prolongation and torsade elgard pointes TdP that should be used cautiously and with close monitoring with eliglustat include leuprolide including leuprolide; norethindrone.
The manufacturer of clozapine recommends caution during concurrent use with medications known to cause QT prolongation.
Because of the potential for TdP, use of dronedarone with leuprolide is contraindicated. Do not inject the medicine if blood is present. Moderate Antipsychotics may cause hyperprolactinemia should not be administered concomitantly with leuprolide since hyperprolactinemia eilgard the number of pituitary GnRH receptors. Cases of QT prolongation and TdP have been reported during postmarketing use of fluvoxamine. After reconstitution, the suspension settles very quickly; therefore, mix and administer the suspension immediately.